Effects of serine protease and deoxyribonuclease on intravascular tumor cell arrest in rat blood-borne lung metastasis.

Invasion & metastasis Pub Date : 1995-01-01
K Tokita, S Sugihara, T Hiraoka, Y Miyauchi, T Kambara, T Yamamoto
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引用次数: 0

Abstract

Effects of alpha-chymotrypsin and deoxyribonuclease I (DNase I) on the early phase of blood-borne lung metastasis in rats were studied using confocal laser scanning microscopy and AH-109A cells labeled either with carboxyfluorescein diacetate succinimyl ester or with 51Cr. Intravenous administration of alpha-chymotrypsin or DNase I appeared to enhance or inhibit, respectively, the tumor cell arrest in lung microvasculature as a reflection of reduction or promotion of the tumor cell clearance in the microvasculature. These results suggest that the effects of alpha-chymotrypsin and DNase I are related to induction of tumor cell aggregation and disaggregation in the blood stream, respectively.

丝氨酸蛋白酶和脱氧核糖核酸酶对大鼠血源性肺转移血管内肿瘤细胞阻滞的影响。
采用共聚焦激光扫描显微镜和51Cr标记的AH-109A细胞,研究了α -胰凝乳蛋白酶和脱氧核糖核酸酶I (DNase I)对大鼠血源性肺转移早期的影响。静脉给药α -凝乳胰蛋白酶或DNase I似乎分别增强或抑制肺微血管中肿瘤细胞的阻滞,反映了微血管中肿瘤细胞清除的减少或促进。这些结果表明,α -凝乳胰蛋白酶和DNase I的作用分别与诱导肿瘤细胞在血流中的聚集和分解有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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