Parasitic infections associated with HIV/AIDS in the Caribbean.

Abstract

This review article seeks to highlight the significance for the Caribbean of major parasitic infections associated with AIDS, encourage awareness of these opportunistic parasites, and promote familiarity with appropriate diagnostic techniques and their clinical relevance. Specific agents considered include Pneumocystis carinii; Toxoplasma gondii; the enteric coccidians Cryptosporidium spp., Isospora belli, and Cyclospora cayetanensis; the hemoflagellates Leishmania spp. and Trypanosoma cruzi; the fungi Histoplasma capsulatum and Cryptococcus neoformans; the nematode Strongyloides stercoralis; and the mite Sarcoptes scabiei. These disease agents can be divided into two groups, the immune-regulated "endogenous" parasites (the protozoans P. carinii and T. gondii, and possibly the roundworm S. stercoralis) and intracellular parasites (including the enteric coccidia, hemoflagellates, and fungi). Both in the Caribbean and elsewhere, the endogenous parasites (particularly P. carinii and T. gondii) are the most troublesome for AIDS patients, partly because they are likely to be transmitted and establish a benign immunoregulated presence early in the subject's life. Indeed, health management programs for AIDS patients often routinely include P. carinii prophylaxis, since nearly all such patients who survive long enough are expected to experience an episode of acute P. carinii infection. In contrast, there is no known epidemiologic association between AIDS and strongyloidiasis in the Caribbean, and the prevalence there of potentially opportunistic hemoflagellates such as Leishmania spp. and Trypanosoma cruzi is relatively low.