Injection of a minuscule dose of FeCl3 within the ventrolateral striatum causes a chronic disturbance of the integrative function within the limbic part of the ventral striatum.

W Kolasiewicz, T Jaros, C Heim, M Melzacka, M Sieklucka, N Weiner, W Wesemann, P Riederer, K H Sontag
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引用次数: 7

Abstract

The present study shows that low amounts of applied iron have a potent effect on the ventrolateral striatum. This is reflected by an influence on spontaneous night activity, cognitive behaviour during the water maze navigation task, exploratory activity and in response to postsynaptic apomorphine stimulation. Such functional disturbances could be observed up to months after a single application of either 0.3 microgram or 1.5 micrograms FeCl3. The low dose of iron stimulates while 1.5 micrograms inhibits the spontaneous dopaminedependent locomotor night and explorative activity. The low concentration of ionic iron injected intrastriatally also increases lipid peroxidation in striatal and hippocampal tissues. These results suggest that the functional integrity of the ventral striatum and the regulation of the iron metabolism are critical for the sensorimotor performance.

在腹侧纹状体内注射小剂量的FeCl3会引起腹侧纹状体边缘部分综合功能的慢性紊乱。
目前的研究表明,低量的应用铁有一个强有力的影响腹侧纹状体。这反映在自发夜间活动、水迷宫导航任务中的认知行为、探索活动和对突触后阿吗啡刺激的反应的影响上。在单次施用0.3微克或1.5微克FeCl3后,可以观察到这种功能紊乱长达数月。低剂量的铁刺激,而1.5微克的铁抑制自发的多巴胺依赖的夜间运动和探索活动。低浓度离子铁注入胃内也增加纹状体和海马组织的脂质过氧化。这些结果表明,腹侧纹状体的功能完整性和铁代谢的调节对感觉运动表现至关重要。
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