MRI Assessment of the Blood-Brain Barrier in a Hamster Model of Scrapie

Neurodegeneration Pub Date : 1995-06-01 DOI:10.1006/neur.1995.0025

Yuen-Li Chung , Alun Williams , John S. Beech , Steve C.R. Williams , Jimmy D. Bell , Jane I. Cox , James Hope

引用次数: 24

Abstract

Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DTPA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results suggest that blood-brain barrier function is disrupted in the clinically-affected animal.

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痒病仓鼠模型血脑屏障的MRI评估

磁共振(MR)成像联合钆-二乙烯三胺五乙酸(Gd-DTPA)增强用于研究仓鼠痒病(263K)临床阶段血脑屏障的完整性。受感染的仓鼠脑的Gd-DTPA后图像显示明显的增强，这在对照动物中不存在。这些结果表明，在临床受影响的动物中血脑屏障功能被破坏。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurodegeneration

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