Tolerance development to phencyclidine by chronic administration

Abstract

• 1.

  1. Tolerance development to phencyclidine (PCP) was assessed in male ICR mice using motor coordination ability as an indicator.

• 2.

  2. The ED50 of PCP for initiating motor incoordination was 13.8 mg/kg and the LD50 of PCP was estimated to be 78 mg/kg.

• 3.

  3. The daily administration of PCP, ranging from 10 to 40 mg/kg, i.p., caused a gradual reduction of the duration of motor incoordination.

• 4.

  4. The degree of tolerance development was observed to be in a dose-dependent fashion.