Theoretical and practical importance of plasma levels of haloperidol. correlations with clinical and computerized EEG data

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90033-3

Rene P. De Buck , Norberto Zelaschi , Christian Gilles , Jacques Durdu , Henri Brauman

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引用次数: 17

Abstract

1.
1. Haloperidol plasma levels, after long acting haloperidol i.m. injection, are analyzed and compared with clinical evolution and EEG modifications.
2.
2. Haloperidol plasma levels were determined by radioimmunoassay. Clinical status was assessed weekly and computerized EEG were performed daily from day 3 to 7 after haloperidol decanoate injection.
3.
3. The plasma level-dose relationship during oral treatment and 4 weeks after haloperidol decanoate injection are very similar. After injection, the plasma level attains its highest value within 3 to 10 days and decreases along a logarithmic curve. An inverse relationship with B.P.R.S.scores is found in many patients. EEG changes are related to clinical status rather than to plasma levels.
4.
4. The results obtained by these three methods are proposed as criteria for the assessment of the reinjection time.

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氟哌啶醇血浆水平的理论和实践重要性。与临床和计算机脑电图数据的相关性

1.1. 分析长效氟哌啶醇静脉注射后氟哌啶醇血浆水平，并与临床发展和脑电图改变进行比较。用放射免疫法测定氟哌啶醇血浆水平。注射癸酸氟哌啶醇后第3 ~ 7天，每周评估临床情况，每天进行脑电图。口服氟哌啶醇治疗期间和注射氟哌啶醇后4周血浆水平剂量关系非常相似。注射后，血浆水平在3 ~ 10天内达到最高值，并沿对数曲线下降。在许多患者中发现与b.p.r.s.评分呈反比关系。脑电图变化与临床状态有关，而与血浆水平无关。这三种方法的结果可作为评价回注时间的标准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Progress in neuro-psychopharmacology

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