Subanesthetic concentration of nitrous oxide and human memory

Mohamed M. Ghoneim , Steven P. Mewaldt , Ronald C. Petersen
{"title":"Subanesthetic concentration of nitrous oxide and human memory","authors":"Mohamed M. Ghoneim ,&nbsp;Steven P. Mewaldt ,&nbsp;Ronald C. Petersen","doi":"10.1016/0364-7722(81)90091-6","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Subanesthetic concentrations of nitrous oxide are used for analgesia and are occasionally abused. The effects of 30% nitrous oxide on human learning and memory, facility for solving mathematical problems and subjective feelings were investigated.</p></span></li><li><span>2.</span><span><p>2. There were 40 normal volunteers; two drugs; 30% nitrous oxide in oxygen (N) and 100% oxygen (P, placebo); and two experimental sessions. Subjects were divided into four groups according to the drug which they inhaled in the two sessions: PP, PN, NP and NN.</p></span></li><li><span>3.</span><span><p>3. “N” produced a marked decrease in learning; mean number of words recalled was 22.9 vs. 50.2 for “P” (P &lt; .001).</p></span></li><li><span>4.</span><span><p>4. On the digit span test, the percent correct under “N” was 63.0 vs. 76.8 under “P” (p&lt; .01), indicating an impairment of short-term memory. “N” also reduced the number of mathematical problems attempted; mean number was 39.0 vs. 52.8 for “P” (p &lt; .002) and reduced the accuracy: 75.5% for “N” vs. 94.8% for “P” (p &lt; .001).</p></span></li><li><span>5.</span><span><p>5. Computation of the difference scores between the number of words learned in Session I and the number recalled in Session II indicated impairment of retrieval under “N”. There was no evidence of state-dependent learning.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90091-6","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900916","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9

Abstract

  • 1.

    1. Subanesthetic concentrations of nitrous oxide are used for analgesia and are occasionally abused. The effects of 30% nitrous oxide on human learning and memory, facility for solving mathematical problems and subjective feelings were investigated.

  • 2.

    2. There were 40 normal volunteers; two drugs; 30% nitrous oxide in oxygen (N) and 100% oxygen (P, placebo); and two experimental sessions. Subjects were divided into four groups according to the drug which they inhaled in the two sessions: PP, PN, NP and NN.

  • 3.

    3. “N” produced a marked decrease in learning; mean number of words recalled was 22.9 vs. 50.2 for “P” (P < .001).

  • 4.

    4. On the digit span test, the percent correct under “N” was 63.0 vs. 76.8 under “P” (p< .01), indicating an impairment of short-term memory. “N” also reduced the number of mathematical problems attempted; mean number was 39.0 vs. 52.8 for “P” (p < .002) and reduced the accuracy: 75.5% for “N” vs. 94.8% for “P” (p < .001).

  • 5.

    5. Computation of the difference scores between the number of words learned in Session I and the number recalled in Session II indicated impairment of retrieval under “N”. There was no evidence of state-dependent learning.

亚麻醉浓度的氧化亚氮和人的记忆
1.1. 亚麻醉浓度的氧化亚氮用于镇痛,偶尔也会被滥用。研究了30%氧化亚氮对人的学习记忆、数学解题能力和主观感受的影响。有40名正常志愿者;两种药物;30%氧化亚氮含氧(N)和100%含氧(P,安慰剂);还有两个实验环节。根据受试者在两个疗程中吸入的药物分为四组:PP、PN、NP和NN.3.3。“N”显著降低了孩子的学习能力;平均回忆单词数为22.9,而“P”为50.2 (P <.4.4措施)。在数字广度测试中,“N”下的正确率为63.0,而“P”下的正确率为76.8。.01),表明短期记忆受损。“N”也减少了尝试数学问题的数量;“P”的平均值为39.0比52.8 (P <.002)并降低了准确率:“N”为75.5%,“P”为94.8% (P <.5.5措施)。通过计算第一阶段学习到的单词数与第二阶段回忆到的单词数的差值,可以看出在“N”条件下,被试的检索能力受损。没有状态依赖学习的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信