Modes and classes of modes of action of physiologically active substances of receptor type under conditions of screening.

Abstract

Questions of the identification of the type of pharmacological activity of physiologically active substances (PAS) with a receptor type of action under conditions of screening are examined. IN accordance with current concepts of the theory of the recognition of modes, the type of action of PAS was identified by establishing a set of criteria ("vectors of modes") characteristic of the effect of known substances and by selecting methods of comparing them with the vectors of the modes of the compounds being tested. Test parameters recorded by the the functional multiparametric method permitting identification of the type of the effects and an evaluation of their quantitative manifestations with the framework of a single experimental approach were used as the unknown set of criteria. The method of describing the relative change in the parameters from the dose as the vectors of action was used and the function of proximity (similarity).