Three-generation reproduction study of rats ingesting 2,4,5-trichlorophenoxyacetic acid in the diet

F.A. Smith, F.J. Murray, J.A. John, K.D. Nitschke, R.J. Kociba, B.A. Schwetz
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引用次数: 9

Abstract

Male and female 4–6-wk-old Sprague-Dawley rats (F0) were fed lab chow containing 2,4,5-T to provide dosage levels of 0, 3, 10 or 30 mg/kg/day for 90 days and were then bred. At day 21 of lactation, pups were randomly selected for the following generation (F1) and the rest were autopsied. Subsequent matings were conducted to produce F2, F3a and F3b litters, successive generations being fed from weaning on the appropriate test or control diet. Fertility was decreased in the matings for the F3b litters in the group on the 10-mg/kg/day dose level. Postnatal survival was significantly decreased in the F2 litters of the 10-mg/kg group and the F1′ F2 and F3a litters of the 30-mg/kg/day group. The relative liver weight of weanlings was significantly increased in the F2′ F3a and Fb litters of the 30-mg/kg/day group. A significant decrease in relative thymus weight was seen only in the Fb generation of this dosage group. Thus, dose levels of 2,4,5-T that were sufficiently high to cause signs of toxicity in neonates had no effect on the reproductive capacity of rats, except for a tendency toward a reduction in postnatal survival at a dose level of 30 mg/kg/day. Reproduction was not impaired at the lowest dose level (3 mg/kg/day).

饮食中摄入2,4,5-三氯苯氧乙酸的大鼠三代繁殖研究
雄性和雌性4 - 6周龄Sprague-Dawley大鼠(F0)分别饲喂含2、4、5-T的实验室饲料,剂量分别为0、3、10和30 mg/kg/d,饲养90 d。在泌乳第21天,随机选择幼鼠作为下一代(F1),其余的进行尸检。随后进行交配,产生F2、F3a和F3b窝,每代断奶后饲喂适当的试验饲粮或对照饲粮。10 mg/kg/d剂量组F3b窝仔的交配繁殖力降低。10 mg/kg组F2窝和30 mg/kg/天组F1 ' F2和F3a窝的产后存活率显著降低。30 mg/kg/d组断奶仔猪F2′F3a和Fb窝的相对肝脏重量显著增加。该剂量组仅在Fb代胸腺相对重量显著下降。因此,足以引起新生儿毒性迹象的2,4,5- t剂量水平对大鼠的生殖能力没有影响,除了在30mg /kg/天的剂量水平下有降低产后存活率的趋势。在最低剂量水平(3mg /kg/天)下,繁殖未受到损害。
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