Haemodynamic reactions after intravenous injection of lorcainide hydrochloride in acute myocardial infarction.

European journal of cardiology Pub Date : 1981-01-01
A Shita, R Bernard, R Mostinckx, M Debacker
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Abstract

Lorcainide hydrochloride given at the doses of 150 mg i.v. proved to be well tolerated at the acute stage of a myocardial infarction; the subjective signs were benign and never prevented us from completing the injection. The haemodynamic changes reflect some depressive effects on the myocardial function. Most of the observed changes are transient, and when significant from the statistical point of view, they remain very mild: the cardiac output decreased from 3.4 to 3.2 l/min per m2, the stroke index from 46 to 41 ml/m2, the pulmonary wedge pressure increases from 6.6 to 8.4 mm Hg (mean values). Lorcainide hydrochloride may thus be used as an antiarrhythmic drug in acute myocardial infarction.

静脉注射盐酸氯卡奈治疗急性心肌梗死后的血流动力学反应。
盐酸氯卡奈150 mg静脉注射证明在心肌梗死急性期耐受性良好;主观征象是良性的,并没有阻止我们完成注射。血流动力学变化反映心肌功能受到一定的抑制作用。大多数观察到的变化是短暂的,从统计学角度来看,当显著时,它们仍然非常轻微:心输出量从3.4降至3.2 l/min /m2,卒中指数从46降至41 ml/m2,肺楔压从6.6上升至8.4 mmhg(平均值)。因此,盐酸氯卡奈可作为抗心律失常药物用于急性心肌梗死。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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