[Electrophysiological study of cardiac effects of succinylcholine: role of vagal tone and hyperkalemia in anesthetized dog (author's transl)].

Anesthesie, analgesie, reanimation Pub Date : 1981-01-01
M Ollagnier, J Descotes, M Lièvre, Q Timour-Chah, G Faucon
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Abstract

The effects of intravenously infused succinylcholine (SCh): 1 mg/kg/minute during 30 minutes were assessed in anesthetized dogs on spontaneous heart rate, conduction within the atrio-ventricular node and the His-Purkinje system and on atrial (AERP) and atrio-ventricular (AVERP) effective refractory periods with varying levels of vagal tone and under mild hyperkalemia. 1) The heart rate which was not affected by SCh in the absence of vagal tone was by contrast increased by 50 p. cent when vagal tone was maintained. Under hyperkalemia, the vagolysis-mediated tachycardia did not prove more marked. 2) The conduction velocity, which was never modified by SCh in either the atria or the His-Purkinje system, was always accelerated with vagal tone. This acceleration is directly related to the vagolytic properties of SCh, but also partly to a mild hyperkalemia. The changes of potassium blood levels tend to reverse the potassium outflow due to the parasympathetic neuromediator. 3) The AERP was was lengthened by SCh and hyperkalemia; the latter impaired the outflow of potassium ions responsible for repolarization. The AVERP was always shortened when the vagal tone is maintained, however less largely under mild hyperkalemia which limits SCh anticholinergic effect owing to its own anticholinergic action.

[琥珀胆碱对心脏作用的电生理研究:迷走神经张力和高钾血症在麻醉犬中的作用[作者译]。
研究麻醉犬30分钟内静脉滴注琥珀酰胆碱(SCh): 1 mg/kg/分钟对自发性心率、房室结传导和His-Purkinje系统以及不同迷走神经张力水平和轻度高钾血症下心房(AERP)和房室(AVERP)有效不应期的影响。1)当迷走神经张力保持时,不受SCh影响的心率增加了50%。在高钾血症下,迷走性心动过速不明显。2)在心房和His-Purkinje系统中,传导速度总是随着迷走神经张力而加速,而不受SCh的影响。这种加速与SCh的迷走神经特性直接相关,但也部分与轻度高钾血症有关。血钾水平的变化倾向于逆转由副交感神经介质引起的钾流出。3) SCh和高钾血症使AERP延长;后者破坏了钾离子的流出,导致复极化。当迷走神经张力维持时,AVERP总是缩短,但在轻度高钾血症下,由于其自身的抗胆碱能作用,限制了SCh的抗胆碱能作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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