[Radio-induced ameloblastic odontosarcoma in the rat. Histological, autoradiographic and ultrastructural study of a case].

Abstract

A case of mandibular ameloblastic odontosarcoma in the rat is reported. This tumor was radio-induced by the local injection of radioactive cerium chloride and had a double ameloblastic and fibrosarcomatous tumour component associated with varying degrees of mineralisation of the dental tissues, enamel, dentine and osteocement. This case is compared with the several human and animal cases reported in the literature. However, the problem of the development of a fibrosarcoma within a pre-existent odontoma remains, even though in the case reported here the ameloblastic epithelial structures appeared to be highly abnormal and neoplastic.