Laser-nephelometric detection of soluble immune complexes.

Abstract

A new method for the detection of soluble immune complexes has been worked out by combining the polyethylene glycol (PEG) precipitation method with laser nephelometry. Experiences achieved by measurements on in vitro immune complexes are presented. The method was found suitable for the detection of immune complexes development in vivo. The optimum concentration of PEG was found to be 3.51%. Results were compared to those achieved by the traditional PEG precipitation technique in 88 cases. The laser nephelometric method was found to be more sensitive and is recommended for use in clinical laboratories.