Tolerance to dextroamphetamine sulfate in hyperactive children: Assessment using an empirical neuropsychological paradigm—a pilot study

Abstract

• 1.

  1. Changes in performance levels on a repeatable battery of neuropsychological tests were used to assess tolerance to dextroamphetamine sulfate in 6 hyperactive children over a 6 week treatment period.

• 2.

  2. An individual ranking system was used to compare performance under an initial dose, both with itself and with another, higher dose, at the end of the treatment period.

• 3.

  3. The results showed no children developed tolerance to the medicine.

• 4.

  4. The usefulness and applicability of the paradigm were discussed.