The ability of amine production by argyrophil cell adenocarcinoma of the endometrium.

Abstract

The ability of amine production of argyrophil cell adenocarcinoma of the endometrium was studied by wet-histofluorescence method. The intense green and yellow fluorescence was detected for the first time in the cytoplasm of a few tumor cells by injecting amine precursor (L-Dopa) 3mg intraperitoneally to nude mice, who were transplanted serially with argyrophil cell adenocarcinoma of the endometrium. Similar fluorescence was also located in a few epithelial cells of the small intestine prepared from the same nude mice. These findings strongly suggested that these fluorescent products were amines. In order to specify the sorts of amines, the microspectrophotometric analyses are now in progress.