Effect of calcitonin on bombesin-stimulated gastric acid secretion in patients with duodenal ulcer.

I Kisfalvi, P Földvári, K Szücs
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Abstract

Intravenous infusion of bombesin (0.9 micrograms/kg/hour) caused a significant increase in gastric acid secretion and serum gastrin concentration in 8 duodenal ulcer patients. Intravenous infusion of calcitonin (2 MRCU/kg/hour) produced a significant decrease in gastric acid output and in integrated gastrin output produced by bombesin infusion (0.9 micrograms/kg/hour) in the same 8 patients with duodenal ulcer. Percentage of inhibition was 49.7 and 40.8, respectively. Simultaneous infusion of calcitonin and bombesin caused no significant difference in serum calcium concentration. It is suggested that the inhibitory effect of calcitonin on acid secretion elicited by bombesin is produced, at least in part, by a fall in serum gastrin caused by bombesin. In addition, calcitonin might directly inhibit the parietal cells by releasing endogenous gastric somatostatin.

降钙素对十二指肠溃疡患者胃粘膜素刺激胃酸分泌的影响。
8例十二指肠溃疡患者静脉滴注bombesin(0.9微克/千克/小时)引起胃酸分泌和血清胃泌素浓度显著升高。8例十二指肠溃疡患者静脉输注降钙素(2 MRCU/kg/h)可显著降低胃酸排泄量,并降低bombesin输注产生的综合胃泌素排泄量(0.9微克/kg/h)。抑制率分别为49.7%和40.8%。同时输注降钙素和血钙素对血钙浓度无显著影响。这表明,降钙素对bombesin引起的酸分泌的抑制作用,至少部分是由bombesin引起的血清胃泌素下降产生的。此外,降钙素可能通过释放内源性胃生长抑素直接抑制壁细胞。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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