Studies on the mechanism of mitochondrial protection by polymeric prostaglandin PGBx.

Physiological chemistry and physics Pub Date : 1982-01-01
H W Shmukler, M G Zawryt, E F Soffer, E Polis, W Feely, S W Kwong, F W Cope
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引用次数: 0

Abstract

On the basis of the interaction between tritiated PGBx and rat liver mitochondria, it appears that PGBx interacts with rat liver mitochondria to form a complex. At low PGBx-mitochondrial ratios, one effect of this complex formation is to stabilize the phosphorylation activity of rat liver mitochondria when exposed for short times to hypotonic solutions. At higher PGBx-mitochondrial ratios, PGBx fails to show this effect. At low PGBx concentrations, PGBx is also shown to inhibit release of amino acids and proteins as well as glutamic acid dehydrogenase and monoamine oxidase from the mitochondria and to inhibit mitochondrial swelling.

聚合前列腺素PGBx对线粒体保护机制的研究。
基于氚化PGBx与大鼠肝脏线粒体的相互作用,认为PGBx与大鼠肝脏线粒体相互作用形成复合物。在低pgbx -线粒体比率下,这种复合物形成的一个作用是在短时间暴露于低渗溶液时稳定大鼠肝脏线粒体的磷酸化活性。在较高的PGBx-线粒体比例下,PGBx没有表现出这种效果。在低浓度的PGBx下,PGBx还显示出抑制线粒体释放氨基酸和蛋白质以及谷氨酸脱氢酶和单胺氧化酶,并抑制线粒体肿胀。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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