[Estrotec--a new immunological test for the study of estrogen in pregnancy].

Abstract

For analysing estrogen in the urine of pregnant women an immunological method based on the principle of hemagglutination inhibition is applied. A total of 45 normal pregnant women were examined to check normal values, along with 30 pregnant women with EPH gestosis. Urine estrogen determinations were made concurrently by an immunological (Estrotec) and a chemical (Ittrich) method. Comparative studies gave satisfactory results, with the linear correlation coefficient r = 0.68 (p 0.05). In normal pregnant women the progressive increase in estrogen values coincided with progressing gravidity. In pregnant women with severe forms of EPH gestosis, estrogen values were in the pathologic range and in accord with the severity of the disorder and the issue of pregnancy.