[Animal experimental studies of the bladder effectiveness of the anticholinergic agent Mictonorm].

Abstract

Pressing need of selectively vesically or spinally acting neuropharmacons exists for patients with neurogenic disturbances of the function of the urinary bladder especially for children with myelomeningocele. The medicament MICTONORM a peripherally effective anticholinergic drug was tested in healthy young pigs with reference to the effect on the storage volume of the bladder. Cystometrograms were recorded in the narcotised experimental animal before and after intravenous application of 0.5 mg MICTONORM per kg body mass. The average increase of the vesical capacity after the drug application amounted to 39.2% (dispersion 6.3 - 95.3%). The values of the vesical pressure showed a nonuniform behaviour. An effect in the afferent part of the vesical reflex arc comes into question for the pharmacon because of the type of action.