[Experimental studies and clinical experiences with homologous tendon grafts preserved with beta-propiolactone].

Abstract

In dog experiments homologous tendon grafts preserved in beta-propiolactone have been examined by means of light-polarisation microscope and electronmicroscope. The histologic data showed that grafts preserved by beta-propiolactone were completely reorganised within 8 weeks after the transplantation similarly to autologous grafts. This process takes place with very little initial inflammatory reaction, followed by fibroblast reaction. The original collagen fibrous framework is decomposed and new tendon is formed by new collagen fibres on this frame. Cicatrisation was not encountered and graft function was excellent. Functional results in 5 patients were investigated 2 years after replacement of the flexor tendons of the hand and were found to be good in 4 cases, satisfactory in 1 case. The results of animal experiments and the excellent experience with preliminary clinical application of the method suggest that homologous tendon grafts preserved in beta-propiolactone may be used for replacement of injured human flexor tendons of the hand.