Double-blind comparative study of clomipramine and amitriptyline in obsessive neurosis

Abstract

• 1.

  1. The efficacy of clomipramine hydrochloride in severe obsessive compulsive neurosis (OCN) was compared with that of amitriptyline in a four week randomized double-blind trial.

• 2.

  2. Clomipramine but not amitriptyline produced statistically significant improvement in the obsessive symptoms, depression and anxiety.

• 3.

  3. The lack of significant effect of amitriptyline on anxiety and depression may be due to its inability to improve the primary obsessive symptoms.

• 4.

  4. No serious adverse effects were encountered in either drug group.