[A cytophotometric study of urothelcells with a combination of MPV and A.S.M. (auther's transl)].

Abstract

The frequency of bladder carcinoma is increasing all over the world. In civilized countries the cause of the increasing frequency is depending on environmental factors of different kinds. The cytologic examination of the urine has proved itself as a screening test for papillomas and carcinomas. With the help of the urine cytology it is possible to detect the cancer of teh bladder frequently at a time, when an operative treatment is still successfull. Tumors of low malignancy (grade I) reveal minor abnormalities and therefore these tumors are often overlooked using cytological methods. For these reasons it is desirable to develop methods for further characterisations of the tumors. Therefore, it appeared useful to examine the applicability of microscopic scanning cytophotometry to discriminate urothelial cells. A special combination of MPV and A.S.M has been built for reasons of interactive segmentation of the cell into nucleus, plasma and background. Computer discrimination between benign, atypical and malignant cells by means of cytophotometry has been accomplished with a small error of classification, not greater than five percent.