Alpha-naphthyl-acetate-esterase reaction for peripheral lymphocytes and monocytes of patients with systemic lupus erythematosus.

E Bodolay, P Boros, G Szegedi
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Abstract

The proportion of T-lymphocytes and monocytes was estimated by the alpha-naphthyl-acetate-esterase-(ANAE)-reaction in blood smears of patients with systemic lupus erythematosus and normal controls. A parallel and significant reduction in the number of T-lymphocytes identified on the basis of both the ANAE and the E-rosette test was found in SLE. In the active periods of SLE more T-cells were identified by the enzyme histochemical study than by the E-rosette test, which points to a functional damage to the T-cells. A marked reduction in the number of the cells considered to be of the suppressor type was demonstrable by both methods in the active period. A distinct reduction in the number of monocytes was also demonstrable by ANAE in the patients with SLE, which may be one of the manifestations of deficient immunoregulation in this disease.

系统性红斑狼疮患者外周血淋巴细胞和单核细胞的α -萘乙酸酯酶反应。
采用α -萘乙酸酯酶(ANAE)反应测定系统性红斑狼疮患者和正常人血涂片中t淋巴细胞和单核细胞的比例。基于ANAE和e -玫瑰花结试验鉴定的t淋巴细胞数量在SLE中发现了平行且显著的减少。在SLE的活动期,通过酶组织化学研究发现的t细胞比通过e -玫瑰花结试验发现的t细胞更多,这表明t细胞的功能受损。在活跃期,两种方法都证明了被认为是抑制型的细胞数量的显著减少。在SLE患者中,ANAE也显示单核细胞数量明显减少,这可能是该疾病免疫调节缺陷的表现之一。
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