The effect of transfer factor on spontaneous shedding of sheep red blood cell binding receptors of T lymphocytes in vitro.

K Nékám, R Varró, K Török, I Láng, L Kalmár, P Gergely, G Petrányi
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Abstract

Many effects of transfer factor can be used for testing of its activity in vitro. Its effect on rosette formation has been utilized in two methods: the enhancement of rosetting of trypsin-treated T lymphocytes and the increase of 'active' rosettes depressed under some immunopathological conditions. 'Active' rosetting lymphocytes of healthy blood donors if kept at 37 degrees C for 4 hr shed partly their sheep red blood cell-binding receptors into the culture medium supplemented with 25% fetal calf serum. The adding of the negative skin test-converting fraction of dialysable leucocyte extracts inhibits the decrease of the number of rosettes. Possible explanations for the observed phenomenon are: transfer factor increases the rate of receptor synthesis, it causes uncovering or redistribution of the receptors, or it stabilizes otherwise shed membrane structures.

转移因子对体外绵羊红细胞结合受体T淋巴细胞自发脱落的影响。
转移因子的许多作用可用于体外活性测试。它对莲座形成的影响已通过两种方法被利用:增强胰蛋白酶处理的T淋巴细胞的莲座形成和增加在某些免疫病理条件下抑制的“活性”莲座形成。健康献血者的“活跃”结瘤淋巴细胞在37℃下保存4小时后,部分羊红细胞结合受体脱落到添加25%胎牛血清的培养基中。加入可透析白细胞提取物的阴性皮试转化分数可抑制莲座数的减少。对观察到的现象可能的解释是:传递因子增加了受体合成的速度,它导致受体的暴露或重新分布,或者它稳定了脱落的膜结构。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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