Charcot-Marie-Tooth's disease with severe trophic and sensory disorders. Study of a case following along a half a century with anatomical studies.

Abstract

Plantar ulcers of neurological origin are known to be associated with several disorders, some of which may be familial. We present the case report together with the clinical and post-mortem data of a patient with peroneal muscular atrophy of the Charcot-Marie-Tooth type and plantar ulcers as a prominent feature. At least three other members of her family had Charcot-Marie-Tooth disease. The family pedigree is included. The discussion stresses the difference between patients with Charcot-Marie-Tooth disease with associated manifestations, bony destruction of the feet and plantar ulcers and patients with hereditary motor and hereditary sensory radicular neuropathies.