[Clinical characteristics of primary hyperlipoproteinemia type IV. An analysis of 86 patients].

M Kusić, M Gavrilović, M Mihajlović, N Marković
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Abstract

In 86 patients with primary HLP type IV over 50% were detected at systematical examinations of non-commissioned officers so that the number of male patients is uncommonly very high, 80, (93%). The highest number of patients--66 (92,5%) belonged to the age group 41-60 years. The analysed group showed the increased incidence of: obesity (60,5%), disturbed glycoregulation (45,3%), arterial hypertension (34,9%), ischemic heart disease (26,7%), hyperuricemia (23%), occlusive peripheral artery disease (16,3%), low values of serum cholesterol concentration LVG (X = 0,98 mmol/l), markedly decreased fibrinolytic activity (eugolobulin fibrinolysis 240 +/- 29 min) and hyperinsulinism (in 9 of 13 patients). Eruptive xanthomas were found in 7 (8,1%) patients. Due to male predominance the incidence of cholelithiasis is lower than expected (8,1%).

原发性高脂蛋白血症IV型临床特点86例分析
在86例原发性HLP IV型患者中,超过50%的患者在士官的系统检查中被发现,因此男性患者的数量非常高,80,(93%)。年龄在41-60岁的患者最多,为66例(92.5%)。分析组显示:肥胖(60.5%)、糖调节紊乱(45.3%)、动脉高血压(34.9%)、缺血性心脏病(26.7%)、高尿酸血症(23%)、闭塞性外周动脉疾病(16.3%)、低血清胆固醇浓度LVG (X = 0.98 mmol/l)、纤溶活性明显降低(高球蛋白纤溶240 +/- 29 min)和高胰岛素血症(13例患者中有9例)的发生率增加。7例(8.1%)患者出现爆发性黄瘤。由于男性居多,胆石症的发病率低于预期(8.1%)。
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