[Comparative kinetics of spleen cell-mediated antibody-dependent cytotoxic activity in mice treated with BCG or Mycobacterium smegmatis].

Abstract

Spleen cells from C3H/HeN mice treated with BCG or Mycobacterium smegmatis displayed similar increased antibody-dependent cellular cytotoxicity (ADCC) in vitro. This activity, which increased between the tenth and the thirty-first day after stimulation, reached twice the amount of ADCC activity developed by the control spleen cells. C3H/HeN mice treated with a complete adjuvant including M. smegmatis and squalene displayed a lower increase in their ADCC capacity (30% instead of 100%).