Functional relationships of the hypothalamic-pituitary-testicular system in Graves' disease.

J Földes, C Bános, T Fehér, L Bodrogi, F Szalay, J Borvendég, J Csillag, J Takó
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Abstract

An increased secretion of gonadotropic hormone was found in hyperthyroid males despite the high basal serum total testosterone and oestradiol levels. This suggests that hyperthyroidism affects the responsiveness of the hypothalamic-pituitary axis to sexual steroid hormones. While in the hyperthyroid patients the elevation of the serum testosterone level in response to chorionic gonadotropin was lower than normally, the LH and FSH responses to LRH were increased. The results indicate that male hyperthyroidism is associated with a loss of responsiveness of the Leydig-cells to adequate stimuli, to which the pituitary reacts by a compensatory increase in its LH-secretion and by an increased reactivity to LRH. It is suggested that in addition to the direct effect of the increased thyroid hormone levels, a secondary elevation of the oestradiol concentration plays a major part in the alterations in question.

下丘脑-垂体-睾丸系统在Graves病中的功能关系。
尽管基础血清总睾酮和雌二醇水平较高,但甲状腺功能亢进的男性促性腺激素分泌增加。这表明甲状腺机能亢进影响下丘脑-垂体轴对性类固醇激素的反应。而甲亢患者对绒毛膜促性腺激素的血清睾酮水平升高低于正常水平,对LRH的LH和FSH反应升高。结果表明,男性甲状腺功能亢进与leydig细胞对足够刺激的反应性丧失有关,垂体通过补偿性增加其lh分泌和增加对LRH的反应性来作出反应。这表明,除了甲状腺激素水平升高的直接影响外,雌二醇浓度的继发性升高在上述变化中起主要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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