Effects of histamine and antihistamines on the kinetics of carbon dioxide in the rat.

Physiological chemistry and physics Pub Date : 1981-01-01
J C Russell, M M Chambers
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Abstract

We have investigated the effects of chlorpheniramine (an H1 histamine inhibitor) and metiamide (an H2 inhibitor) on response to 14C pulse-labeling of carbon dioxide in the rat in the presence and absence of histamine. Neither chlorpheniramine nor metiamide alone had any effect upon the gastric venous/arterial ratio (VG/A) or the peripheral venous/arterial ratio (Vp/A). As in the case with no drug present, Vp/A rose with time following pulse-labeling to a value of 1.15-1.20. The presence of a preexisting steady-state infusion of histamine caused no changes in the ratios in the presence or absence of the inhibitors. The inhibitors did completely abolish the oscillations of both VG/A and Vp/A caused by initiation of histamine infusion coincident with the pulse-labeling. The results suggest that the histamine effects are largely mediated through H1 receptors.

组胺和抗组胺药对大鼠体内二氧化碳动力学的影响。
我们研究了chlorpheniramine(一种H1组胺抑制剂)和metiamide(一种H2抑制剂)在存在和不存在组胺的情况下对大鼠二氧化碳14C脉冲标记反应的影响。单独使用氯苯那敏或甲氨酰胺对胃静脉/动脉比值(VG/A)或外周静脉/动脉比值(Vp/A)均无影响。与没有药物存在的情况一样,在脉冲标记后,Vp/A随着时间的推移而上升,达到1.15-1.20。在存在或不存在抑制剂的情况下,预先存在的稳定状态组胺输注的存在不会引起比例的变化。抑制剂确实完全消除了与脉冲标记一致的组胺输注起始引起的VG/A和Vp/A的振荡。结果表明组胺的作用主要是通过H1受体介导的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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