Estradiol-17 beta and estradiol-17-glucosiduronate before and at delivery.

H Okada, H Honjo, J Yasuda, K Otsubo, K Omori, K Tsukamoto, T Yamamoto, M Numazawa, T Nambara
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Abstract

The maternal peripheral serum level of estradiol-17 beta (E2), which reaches a peak a few weeks before delivery, may play a role in initiating delivery. In this study, the steroidal activity regulated by both the production and conjugation was estimated by measuring estradiol-17-glucosiduronate (E2-17-G), E2, estriol-16-glucosiduronate (E3-16-G), and estriol (E3) before and at delivery. At delivery, levels of E2 and E2-17-G were higher in the maternal peripheral vein (MP) than in the umbilical vein (UV) and umbilical artery (UA), but those of E3 and E3-16-G were higher in UV and UA than in MP. These results suggested that the production and conjugation of E2 were mainly regulated on the maternal side, but those of E3 were regulated mainly in the feto-placental unit. The ratios of E2/E2-17-G in MP were or became high a few weeks before delivery but decreased remarkably as pregnancy progressed to delivery. The activity of E2 seems to be regulated at least in part by conjugation in late pregnancy and at delivery.

分娩前后雌二醇-17 β和雌二醇-17-葡萄糖苷酸。
母体外周血清雌二醇-17 β (E2)水平在分娩前几周达到峰值,可能在启动分娩中起作用。本研究通过测定分娩前和分娩时雌二醇-17-葡萄糖苷酸(E2-17- g)、E2、雌二醇-16-葡萄糖苷酸(E3-16- g)和雌三醇(E3)的含量,估计了生产和偶联所调节的甾体活性。分娩时,E2和E2-17- g在母体外周静脉(MP)中的水平高于脐静脉(UV)和脐动脉(UA),而E3和E3-16- g在UV和UA中的水平高于MP。这些结果表明E2的产生和结合主要受母体调控,而E3的产生和结合主要受胎胎盘单位的调控。MP中E2/E2-17- g的比值在分娩前几周升高或升高,但随着妊娠至分娩显著下降。E2的活性似乎至少在一定程度上受到妊娠后期和分娩时的结合的调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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