Treatment of uncomplicated anogenital gonorrhoea with a single oral dose of 3 g amoxycillin combined with 250 mg clavulanic acid.

Abstract

Sir, The importance of Chlamydia trachomatis in genital tract infections is well established.1-4 The humoral immune responses during chlamydial infections have been examined with several serological techniques,5 and in vitro cellular immune responses to chlamydial antigens in man have been studied with different assays.6-8 We report on the immune response after local and more severe chlamydial infections. One group of patients consisted of 10 women who had had acute salpingitis 1-2 years before, probably caused by C trachomatis. The women had had a positive chlamydial culture from the cervix and a fourfold or more rise in chlamydial IgG antibody titre during the disease. The other group consisted of 10 women who 1-2 months earlier had had chlamydial cervicitis, with only lower genital tract symptoms. T cells and non-T cells were prepared from defibrinated blood, as described previously.8 A suspension of partially purified C trachomatis subtype LGV-2 was used as antigen throughout the study.8 An enzyme