Effects of a metastatic (13762) and nonmetastatic (R3230AC) mammary adenocarcinoma on radiocolloid localization in regional lymph nodes in Fischer 344 rats.

G N Ege, J B Nold, R R Eng, A Durakovic, J J Conklin
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Abstract

Effects of a metastatic and nonmetastatic tumor on radiocolloid localization in regional lymph nodes in the rat were studied in order to examine further the hypothesis that suppression of radiocolloid uptake results from inhibition of macrophage phagocytic function by tumor products. On the basis of data obtained in the present model using homogenates of autologous spleen and two weakly immunogenic tumors introduced into the foot pad of rats, it is proposed that decreased radiocolloid uptake induced by a regional neoplasm may result from proliferation of nonphagocytic cellular elements within the regional lymph nodes and alterations in the cell population at the site of radiocolloid injection, which impede the transport of interstitially administered radiocolloid and its access to phagocytic macrophages, within primary and secondary regional lymph nodes. In its inception, therefore, suppression of radiocolloid uptake is not unique to neoplasia and may not directly reflect altered phagocytosis.

转移性(13762)和非转移性(R3230AC)乳腺腺癌对Fischer 344大鼠区域淋巴结放射性胶质定位的影响
研究了转移性和非转移性肿瘤对大鼠局部淋巴结放射性胶体定位的影响,以进一步验证肿瘤产物抑制巨噬细胞吞噬功能导致放射性胶体摄取抑制的假设。本模型采用自体脾脏匀浆和两种弱免疫原性肿瘤植入大鼠足垫,根据所获得的数据,提出区域性肿瘤诱导的放射性胶体摄取减少可能是由区域淋巴结内非吞噬细胞成分的增殖和放射性胶体注射部位细胞群的改变引起的。在原发性和继发性区域淋巴结内,它们阻碍了间质给药的放射性胶质的运输及其进入吞噬巨噬细胞。因此,一开始,放射性胶体摄取的抑制并不是肿瘤所特有的,也可能不能直接反映吞噬作用的改变。
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