Reactivity of thymic metallophilic cells during the regeneration after the application of cyclophosphamide.

N M Milićević, Z Milićević, O Piletić, S Mujović, V Ninkov
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Abstract

Metallophilic cells, which had dendritic morphology in vivo, were localized almost exclusively in the cortico-medullary zone of the control rat thymus. The patterns of thymic regeneration after a single (300 mg/kg) or consecutive injections (5 X 60 mg/kg) of Cyclophosphamide were well correlated with the changes in the number and topographical distribution of the metallophilic cell population. The specific staining with aldehyde fuchsin of metallophilic cells diffusely distributed throughout the cortex during the regeneration clearly demonstrated that these cells were identical with aldehyde fuchsin-positive metallophilic cells in the cortico-medullary zone of the normal rat thymus. The results presented suggest that metallophilic cells play some role in the process of normal thymocytopoiesis and represent a hitherto undescribed component of the thymic microenvironment.

应用环磷酰胺后胸腺亲金属细胞再生过程中的反应性。
在体内具有树突状形态的亲金属细胞几乎全部位于对照大鼠胸腺皮质-髓质区。单次(300 mg/kg)或连续注射(5 × 60 mg/kg)环磷酰胺后胸腺再生模式与嗜金属细胞群数量和地形分布的变化有良好的相关性。对再生过程中弥散分布于皮层的亲金属细胞进行醛品红特异性染色,清楚地表明这些细胞与正常大鼠胸腺皮质-髓质区醛品红阳性的亲金属细胞相同。结果表明,嗜金属细胞在正常胸腺细胞生成过程中起一定作用,是胸腺微环境中迄今未被描述的组成部分。
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