Levels of interaction between schizophrenia and manic-depressive disease.

Abstract

Interaction between schizophrenia and manic-depressive disease (MDI) has to be examined with respect to type, intensity and time points within the courses. Interactions are possible at the level of genetics, constitution, biological (e.g. biorhythmical) mechanisms, neurophysiological actions, biochemical complexes and psychopathological interferences including defense mechanisms of personality. The common denominator seems to be the energetic situation into the satellite-glia-neuron cooperation. Activity of G6PD and AK 2-1 could be a hint of a factor of bipolarity, existing independently from schizophrenia and MDI. Interactions of different psychoses should be designated as interference psychoses. Within this field, the term schizoaffective characterizes the interference between schizophrenia and MDI, mixed psychoses mean stages of rapidly alternating or stable combinations of symptoms within the MDI. 'Legierungspsychosen' should be reserved for interferences at the genetic level.