A dual vial waveguide exposure facility for examining microwave effects in vitro.

S T Lu, N J Roberts, S M Michaelson
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引用次数: 5

Abstract

A waveguide exposure system operated between 2 and 4 GHz was assembled in a laboratory incubator in order to study potential temperature-dependent and temperature-independent actions of microwaves. Two vials containing cell cultures were exposed simultaneously in a single waveguide in order to reduce the space required, and to allow concurrent study of autologous cell cultures in two different functional states (resting and stimulated) during exposure. Dosimetry was performed using three techniques with different underlying assumptions, as well as the technique of differential power measurement. Each of the four techniques yielded different results, although differences between the two vials using any single technique were negligible. A significant 'hot spot' occurred at the center of each vial. The ratio between maximum and minimum absorption rate within a single vial was 33-fold using a vial of 1.2-cm diameter and 1.6-cm height. With agitation and exposure at specific absorption rate (SAR) equal to 21 mW/ml, the thermal gradient was less than 0.1 degrees C between these two points. The averaged SAR can be determined by steady-state heating analysis. The exposure system can be calibrated readily by calculation for the measured powers, but not by differential power measurement.

一种用于检测体外微波效应的双瓶波导暴露装置。
在实验室培养箱中组装了工作频率在2 ~ 4ghz之间的波导曝光系统,以研究微波的温度依赖性和温度依赖性的潜在作用。两个装有细胞培养物的小瓶同时暴露在一个波导中,以减少所需的空间,并允许在暴露期间同时研究两种不同功能状态(静息和刺激)的自体细胞培养物。剂量测定采用三种不同假设的技术,以及差分功率测量技术。四种技术中的每一种都产生了不同的结果,尽管使用任何一种技术的两个小瓶之间的差异可以忽略不计。每个小瓶的中心都有一个明显的“热点”。在直径1.2 cm、高1.6 cm的小瓶中,单瓶内最大吸收率与最小吸收率之比为33倍。在特定吸收率(SAR)为21 mW/ml的搅拌和暴露条件下,两点之间的热梯度小于0.1℃。平均SAR可以通过稳态加热分析确定。曝光系统可以很容易地通过计算测量功率来校准,但不能通过差分功率测量来校准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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