I Hirono, S Aiso, T Yamaji, H Mori, K Yamada, H Niwa, M Ojika, K Wakamatsu, H Kigoshi, K Niiyama
{"title":"Carcinogenicity in rats of ptaquiloside isolated from bracken.","authors":"I Hirono, S Aiso, T Yamaji, H Mori, K Yamada, H Niwa, M Ojika, K Wakamatsu, H Kigoshi, K Niiyama","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The nature of the carcinogen present in bracken fern has not yet been elucidated. Very recently, we succeeded in isolating ptaquiloside, a novel norsesquiterpene glucoside of the illudane type, from bracken. Ptaquiloside was shown to be a carcinogenic principle of bracken fern. It induces mammary cancer and multiple ileal tumors in high incidences when given orally to female Sprague-Dawley rats.</p>","PeriodicalId":12660,"journal":{"name":"Gan","volume":"75 10","pages":"833-6"},"PeriodicalIF":0.0000,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gan","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The nature of the carcinogen present in bracken fern has not yet been elucidated. Very recently, we succeeded in isolating ptaquiloside, a novel norsesquiterpene glucoside of the illudane type, from bracken. Ptaquiloside was shown to be a carcinogenic principle of bracken fern. It induces mammary cancer and multiple ileal tumors in high incidences when given orally to female Sprague-Dawley rats.
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