Enhancing effect of sodium taurocholate on N-methyl-N'-nitro-N-nitrosoguanidine-induced stomach tumorigenesis in rats.

Abstract

Male Wistar rats that had received a low dose of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and sodium taurocholate showed a significantly higher incidence of hyperplastic and neoplastic lesions in the stomach mucosa than did the MNNG-treated controls. The result suggested an enhancing effect of taurocholate in stomach tumorigenesis.