Behaviour of a Trypanosoma brucei brucei stock (STIB 348C) in mice. 4. Different course of primary parasitemia in trypanosome variants of different virulence.

Tropenmedizin und Parasitologie Pub Date : 1984-06-01
W Büngener
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Abstract

In three types of trypanosomes with low virulence, trypanosome numbers increased by a factor of 18-21 per day on average during prepatency and by a factor of 70-219 on average from the first to second day of patency. By contrast, a very virulent trypanosome variant showed an average increase of trypanosome numbers per day by 32 and 28 during prepatency and early patency, respectively. --In detailed studies, trypanosomes of low virulence exhibited a rapidly rising parasitemia in early patency which lasted for 20-30 hours and was followed by a plateau of slowly rising and falling parasitemia. Trypanosomes of high virulence showed a constant logarithmic increase of their numbers, slowing down at concentrations above antilog 5.5 per microliters of blood. In mild trypanosomes with peak parasitemias of antilog 5-5.7 per microliters of blood, after low dose infections the primary parasitemia was abruptly terminated after 70-100 hours of patency, obviously by the action of antibody. After massive infections, the parasitemia was terminated at 109-122 hours after infection. --In trypanosomes with higher peak parasitemias, primary parasitemias were seen to last longer, in some cases for 7 to 12 days. --Mice infected with low doses of highly virulent trypanosomes died with high parasitemias after some 60-90 hours of patency, before antibodies could normally become effective. After massive infections they died at 40-60 hours after infection. There is clearly no need to invoke non-immunogenicity of these trypanosomes or immunosuppression by these trypanosomes to explain this course of the infection.

布鲁氏锥虫种群(STIB 348C)在小鼠体内的行为。4. 不同毒力的锥虫变异体原发寄生虫病的不同病程。
在三种低毒力型锥虫中,锥虫数量在准备期间平均每天增加18-21倍,在开放的第一天至第二天平均增加70-219倍。相比之下,一种非常毒力的锥虫变体在准备和开放早期分别显示每天平均增加32和28个锥虫数量。在详细的研究中,低毒力的锥虫在开放早期表现出快速上升的寄生虫血症,持续20-30小时,随后是缓慢上升和下降的平台期。高毒力锥虫的数量呈恒定的对数增长,浓度高于每微升血液5.5安替洛格时减慢。在轻度锥虫中,每微升血中最高寄生数为5 ~ 5.7个,低剂量感染后,初代寄生在70 ~ 100小时后突然终止,明显是由于抗体的作用。大量感染后,寄生虫病在感染后109 ~ 122小时终止。在寄生高峰较高的锥虫中,初级寄生持续时间更长,在某些情况下可持续7至12天。感染了低剂量高毒性锥虫的小鼠,在抗体正常生效之前,在大约60-90小时的开放后,因高寄生虫率而死亡。大规模感染后,它们在感染后40-60小时内死亡。显然,没有必要援引这些锥虫的非免疫原性或这些锥虫的免疫抑制来解释这一感染过程。
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