Inhibition of rat mammary tumor growth by purified protein A--a potential anti-tumor agent.

Immunological communications Pub Date : 1983-10-01 DOI:10.3109/08820138309051962

P K Ray, S K Bandyopadhyay

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引用次数: 44

Abstract

Intravenous inoculations of purified Protein A of Staphylococcus aureus Cowan I cause significant (p less than 0.01) regression of di-methyl-benz-anthracene (DMBA)-induced mammary adenocarcinomas in Sprague-Dawley rats. Direct tumor cell counts of treated tumors showed fewer (p less than 0.005) viable tumor cells than did tumors from untreated controls. Plasma immunoglobulin G concentration showed a significant (p less than 0.05) increase compared to that of controls. However, the concentration of immune complexes and percentages of T-rosettes did not change. Peripheral blood mononuclear cells (PBMNC) from treated animals showed increased cytotoxicity (p less than 0.005) compared to that of controls. Plasma of treated animals potentiated PBMNC cytotoxicity (p less than 0.05) and showed increased antibody and complement-mediated cytotoxicity (p less than 0.025). The exact mechanism of protein A-induced potentiation of anti-tumor immune reactivities leading to tumoricidal response is not known. However, our data are suggestive of the involvement of both cellular and humoral immunity of the host in the tumor regressive phenomenon.

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纯化蛋白A-一种潜在的抗肿瘤剂对大鼠乳腺肿瘤生长的抑制作用。

经静脉注射纯化的金黄色葡萄球菌Cowan I蛋白A可使二甲基苯蒽(DMBA)诱导的乳腺腺癌在Sprague-Dawley大鼠中显著(p < 0.01)消退。经治疗的肿瘤直接肿瘤细胞计数显示活的肿瘤细胞少于未经治疗的对照组(p < 0.005)。血浆免疫球蛋白G浓度与对照组相比显著升高(p < 0.05)。然而，免疫复合物的浓度和t -莲座的百分比没有变化。与对照组相比，经处理的动物外周血单个核细胞(PBMNC)的细胞毒性增加(p < 0.005)。血浆增强PBMNC细胞毒性(p < 0.05)，抗体和补体介导的细胞毒性增加(p < 0.025)。蛋白a诱导的抗肿瘤免疫反应增强导致肿瘤杀伤反应的确切机制尚不清楚。然而，我们的数据提示宿主的细胞免疫和体液免疫参与肿瘤消退现象。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Immunological communications

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