Correlation between mixed lymphocyte cultures and anti-Epstein Barr virus (EBV) antibodies in Hodgkin's disease and non Hodgkin lymphoma patients.

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-10-01

M C Sasiain, M Fejes, B R Ares, D Brezavscek, A E Bachmann

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Abstract

Cellular and humoral immunity was examined in Hodgkin's disease and non Hodgkin lymphoma (33) patients and compared with a normal group. Mixed lymphocyte cultures (MLC) were used as parameter for cell mediated immunity and anti-Epstein Barr virus (EBV) antibodies for specific humoral immunity. High stimulation indices coincided with low anti-VCA and anti-EBNA titers in the control group (r = -0.343). This negative correlation was not found in non Hodgkin lymphomas and was substantially lower (r = -0.142) in Hodgkin's disease. The alterations in immunoregulatory mechanisms in these patients are discussed.

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霍奇金病和非霍奇金淋巴瘤患者混合淋巴细胞培养与抗eb病毒抗体的相关性

对霍奇金病和非霍奇金淋巴瘤(33例)患者进行细胞免疫和体液免疫检查，并与正常组进行比较。混合淋巴细胞培养(MLC)作为细胞介导免疫的参数，抗eb病毒(EBV)抗体作为特异性体液免疫的参数。高刺激指数与对照组低抗vca和抗ebna滴度相吻合(r = -0.343)。这种负相关在非霍奇金淋巴瘤中未发现，在霍奇金病中显著降低(r = -0.142)。讨论了这些患者免疫调节机制的改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomedicine / [publiee pour l'A.A.I.C.I.G.]

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