Growth factors and the vessel wall.

S M Schwartz, C M Gajdusek
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Abstract

We have tried to review the large and complex literature on vessel wall growth from the viewpoint of humoral factors. The picture is both simple and complex. Two growth factors, PDGF and EGF, can now be chemically defined, and we have begun to understand the way they interact with cells. For one of these growth factors, PDGF, there is good evidence that it has access to the vessel wall and can promote cell replication. The story of other factors is more complex. We still know very little about growth inhibitors, and there is no conclusive evidence that they exist as functional entities in vivo. The work on heparan sulphate could represent the first clear example of negative control of growth. Of the large variety of other factors, it is likely that macrophage-derived growth factor is produced in the vessel wall, and it is possible that the endothelial cell-derived growth factor is made in vivo as well as in vitro. Perhaps our greatest challenge in the near future will be to learn the relative role of each of these factors, as well as their interactions with one another during the progression of atherosclerotic lesions.

生长因子和血管壁。
我们试图从体液因素的角度回顾大量复杂的关于血管壁生长的文献。这幅图画既简单又复杂。两种生长因子,PDGF和EGF,现在可以用化学方法定义,我们已经开始了解它们与细胞相互作用的方式。对于其中一种生长因子PDGF,有充分的证据表明它可以进入血管壁并促进细胞复制。其他因素的情况更为复杂。我们对生长抑制剂仍然知之甚少,也没有确凿的证据表明它们在体内作为功能实体存在。对硫酸肝素的研究可能是负控制生长的第一个明确例子。在种类繁多的其他因子中,巨噬细胞衍生的生长因子很可能是在血管壁上产生的,内皮细胞衍生的生长因子也可能是在体内和体外产生的。也许在不久的将来,我们最大的挑战将是了解这些因素的相对作用,以及它们在动脉粥样硬化病变进展过程中的相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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