Biochemistry of chronic jejunal ulcer in patients.

G Mózsik, L Nagy, F Tárnok, J Kutas
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Abstract

Separation and measurement of adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenine-adenosine, lipid phosphates (lipid P), ribonucleic acid (RNA), deoxyribonucleic acid (DNA), further of Mg2+-dependent, total (Mg2+-dependent plus Na+-K+-dependent) and Na+-K+-dependent ATPases was carried out in control (non-ulcerated) and ulcerated (mucosa up to 2.0 cm around the ulcer) jejunal mucosa of 11 patients with chronic jejunal ulcer, who had undergone a Billroth II gastric resection for duodenal ulcer. The levels of ATP, ADP, AMP, sum of ATP + ADP + AMP, lipid-P, RNA (related to 1.0 mg DNA) and the activity of Mg2+-dependent, total (Mg2+-dependent plus Na+-K+-dependent) and Na+-K+-dependent ATPase (related to 1.0 mg membrane protein) were significantly higher in the lacerated jejunal mucosa than in the control one. The results indicate that (1) no circulatory damage can be found in the ulcerated jejunal mucosa; (2) a cellular hyperactivity (increased ATP breakdown and increased ATP resynthesis, increased RNA and lipid synthesis) occurs in the ulcerated jejunal mucosa; (3) the biochemical structure of cells differs significantly in the control and the ulcerated jejunal mucosa.

慢性空肠溃疡患者的生物化学特征。
对11例慢性空肠溃疡患者的对照(未溃疡)和溃疡(溃疡周围2.0 cm)空肠黏膜进行三磷酸腺苷(ATP)、二磷酸腺苷(ADP)、单磷酸腺苷(AMP)、腺嘌呤-腺苷、脂质磷酸(脂质P)、核糖核酸(RNA)、脱氧核糖核酸(DNA)以及Mg2+依赖性、总(Mg2+依赖性加Na+-K+依赖性)和Na+-K+依赖性ATP酶的分离和测定。她因十二指肠溃疡接受了比尔罗斯II型胃切除术。空肠裂伤黏膜的ATP、ADP、AMP水平、ATP + ADP + AMP总和、脂质p、RNA(与1.0 mg DNA相关)和Mg2+依赖性、总(Mg2+依赖性加Na+-K+依赖性)和Na+-K+依赖性ATP酶(与1.0 mg膜蛋白相关)活性均显著高于对照组。结果表明:(1)溃烂的空肠黏膜未见循环损伤;(2)空肠粘膜溃疡发生细胞亢进(ATP分解增加,ATP再合成增加,RNA和脂质合成增加);(3)对照组与溃疡组空肠黏膜细胞生化结构差异显著。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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