[Effect of oral almitrine on the sleep apnea syndrome].

P Mangin, J Krieger, D Kurtz
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引用次数: 0

Abstract

Almitrine stimulates breathing by activating peripheral chemoreceptors and was given orally in a dose of 200 mg/day to nine patients with sleep apnoea syndrome, after a single blind placebo sequence. No reduction in the number of respiratory events per hour of sleep was observed. On the other hand Almitrine led to a significant fall in the mean duration of respiratory events (p less than 0.02). This fall occurred principally in the obstructive apnoea group and in those with mixed apnoea only during light slow wave sleep. These results are in agreement with the hypothesis that the arousal response to hypoxia mediated by the chemoreceptors could be responsible for the termination of sleep apneas.

[口服丙三嗪对睡眠呼吸暂停综合征的影响]。
Almitrine通过激活外周化学感受器刺激呼吸,在单盲安慰剂序列后,以200毫克/天的剂量口服给9名睡眠呼吸暂停综合征患者。没有观察到每小时睡眠呼吸事件的数量减少。另一方面,Almitrine导致呼吸事件平均持续时间显著下降(p < 0.02)。这种下降主要发生在阻塞性呼吸暂停组和仅在光慢波睡眠期间出现混合性呼吸暂停的组。这些结果与化学感受器介导的缺氧唤醒反应可能是睡眠呼吸暂停终止的原因的假设一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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