{"title":"New Thy-1- and H-2-congenic strains of mice and their application in studies on the mechanism of anti-Thy-1.1 response.","authors":"J S Reichner, T J Gorzynski, M B Zaleski","doi":"10.3109/08820138309051967","DOIUrl":null,"url":null,"abstract":"<p><p>The magnitude of the primary humoral anti-Thy-1.1 responses was measured by the number of PFC in spleens of B10.S(7R) mice and some of their H-2 heterozygous F1 hybrids immunized with thymocytes of either AKR.TH or B10.S(7R)-Thy-1a strain. These two of the five newly developed strains are non-H-2 incompatible and non-H-2 compatible with B10.S(7R) mice, respectively. The low anti-Thy-1.1 responses of B10.S(7R) mice and their F1 hybrids after immunization with thymocytes from non-H-2 compatible B10.S(7R)-Thy-1a donors indicated that the I-As \"allele\" of B10.S(7R) mice and the I-A \"alleles\" of other parental strains tested did not produce a complementary effect that is required for non-H-2 compatible thymocytes to elicit a good anti-Thy-1 response.</p>","PeriodicalId":13417,"journal":{"name":"Immunological communications","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08820138309051967","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunological communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/08820138309051967","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
The magnitude of the primary humoral anti-Thy-1.1 responses was measured by the number of PFC in spleens of B10.S(7R) mice and some of their H-2 heterozygous F1 hybrids immunized with thymocytes of either AKR.TH or B10.S(7R)-Thy-1a strain. These two of the five newly developed strains are non-H-2 incompatible and non-H-2 compatible with B10.S(7R) mice, respectively. The low anti-Thy-1.1 responses of B10.S(7R) mice and their F1 hybrids after immunization with thymocytes from non-H-2 compatible B10.S(7R)-Thy-1a donors indicated that the I-As "allele" of B10.S(7R) mice and the I-A "alleles" of other parental strains tested did not produce a complementary effect that is required for non-H-2 compatible thymocytes to elicit a good anti-Thy-1 response.
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