Amino acid transport by the small intestine of the rat on the counterflow phenomenon as a cause of the accelerating effect of leucine on the transintestinal transport of diamino acids

Abstract

The accelerating effect of leucine on the transintestinal transport of lysine has been studied.

The relationship of the transport of lysine to that of leucine was such as would be expected if the accelerating effect of leucine was a result of the combined function of the transport mechanisms of the neutral and the diamino acids. Of the two transport mechanisms that of the neutral amino acids created and maintained, on the serosal side of the transport mechanisms, a concentration of leucine sufficient to exert a counterflow effect on the transport of lysine by the transport mechanism of the diamino acids.

The transintestinal transport of arginine and ornithine was accelerated by leucine to the same extent as that of lysine.