The pathogenesis route of migration, and development of Crenosoma vulpis in the dog.

Abstract

In the dog infective larvae of Crenosoma vulpis migrate from the stomach to the lungs via the hepatic portal vein, hepatic parenchyma, hepatic vein, heart, and pulmonary circulation, arriving in the lungs as early as 6 h after infection. Third-stage larvae induce the formation of necrotic foci throughout the liver during the first 24 h after infection. The discarded cuticles of the third-stage larvae elicit granulomata which become the centre of foci of interstitial pneumonia. Adult C. vulpis cause bronchitis and bronchiolitis.