Pathology of locoweed (Astragalus lentiginosus) poisoning in sheep. Sequential development of cytoplasmic vaculation in tissues.

Abstract

Sheep experimentally poisoned by ingestion of Astragalus letiginosus developed cytoplasmic vacuolation of the proximal tubular epithelia within 4 days after beginning of the experiment. Neuronal vacuolation occurred by day 8 and had progressed to neuronolysis by day 16.