The association pattern of the Ph chromosome.

Abstract

A total of 951 Ph1+ cells and 364 Ph1–cells from a female patient with chronic myelogenous leukemia was scored for acrocentric associations. The Ph1+ and Ph1-cells differed significantly in their association patterns. The average number of association groups per cell, the average size of the groups, and the total number of chromosomes involved in associations per cell were significantly lower in the Ph1+ cells. Although the Ph1 chromosome itself tended to be found in association more often than expected by chance, it appeared to associate at random with the other acrocentrics.