The phenomenon of nucleolar segregation in some lesions of the thyroid cell.

Abstract

Study in the electron microscope of certain human thyroid lesions showed that the phenomenon of nucleolar segregation is comparatively frequent in sporadical or diffuse nodular goitres, in familial goitres and cancer of the thyroid. The reorganization and redistribution of the nucleolar material, reflecting deep alterations in the metabolism of ribonucleic acid, are proper to hypofunctional thyropathies. The intensity of segregation increases in proportion to neoplastic transformation of the thyroid cell.