Evaluation of (o)-[77Br]bromohippuran as renal tubular function agent

The International journal of applied radiation and isotopes Pub Date : 1985-09-01 DOI:10.1016/0020-708X(85)90044-4

A. van Aswegen , A.J. Van Wyk , J.P. Roodt , H. Pieters , C.P. Herbst , A.C. Otto , M.G. Lötter , F.J. Haasbroek , P.C. Minnaar , P.J. Fourie

引用次数: 3

Abstract

(o)-[⁷⁷Br]bromohippuran (BHIP) was developed as renal tubular function agent due to its favourable chemical and physical properties and compared to (o)-[¹³¹I]iodohippuran (IHIP). Renograms obtained from baboons were compared and absorbed radiation dose calculations performed. Although BHIP showed a delayed kidney uptake and washout pattern, good kidney clearance of the radionuclide was obtained after 30 min. Radiation dose values for BHIP were markedly lower than for IHIP indicating that larger activities of BHIP could be administered to increase counting statistics. BHIP imaging in normal volunteers did however not substantiate the favourable behaviour obtained in the primate.

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(o)-[77Br]溴希波兰作为肾小管功能剂的评价

(o)-[77Br]溴希波兰(BHIP)与(o)-[131I]碘希波兰(IHIP)相比，具有良好的化学和物理性能，被开发为肾小管功能剂。比较了从狒狒获得的肾图，并计算了吸收的辐射剂量。尽管BHIP表现出延迟的肾脏摄取和冲洗模式，但30分钟后获得了良好的放射性核素肾脏清除率。BHIP的辐射剂量值明显低于IHIP，表明可以给予较大的BHIP活性以增加计数统计。然而，正常志愿者的BHIP成像并没有证实在灵长类动物身上获得的有利行为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The International journal of applied radiation and isotopes

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